.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AA02_Chlortetracycline.Chlortetracycline

Information

Chlortetracycline is a broad-spectrum tetracycline antibiotic, formerly used for treating bacterial infections in humans and animals, especially for eye infections (ophthalmic use). Due to resistance and adverse effects, its systemic human use is now rare and it is primarily used topically or in veterinary medicine. It is not currently a first-line approved drug for systemic human use.

Pharmacokinetics

No peer-reviewed human pharmacokinetic study available for chlortetracycline; pharmacokinetic parameters are estimated based on similarities with other tetracyclines and limited historical reports.

References

1. Zhang, Y, et al., & Yu, M (2022). Florfenicol/Chlortetracycline Effect on Pharmacodynamic Indices for Mutant Selection of . Microbial drug resistance (Larchmont, N.Y.) 28(7) 832–840. DOI:10.1089/mdr.2022.0008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35723674

2. Cazer, CL, et al., & Gröhn, YT (2018). Expanding behavior pattern sensitivity analysis with model selection and survival analysis. BMC veterinary research 14(1) 355–None. DOI:10.1186/s12917-018-1674-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/30453986

3. Cazer, CL, et al., & Gröhn, YT (2017). Monte Carlo Simulations Suggest Current Chlortetracycline Drug-Residue Based Withdrawal Periods Would Not Control Antimicrobial Resistance Dissemination from Feedlot to Slaughterhouse. Frontiers in microbiology 8 1753–None. DOI:10.3389/fmicb.2017.01753 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29033901

Revisions

• 06/2025 initial generated model