.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AA11_Gentamicin.Gentamicin

Information

Gentamicin is an aminoglycoside antibiotic used to treat serious gram-negative bacterial infections and some gram-positive infections. It is commonly administered by intravenous or intramuscular routes in hospital settings. Gentamicin is approved for clinical use and remains a standard treatment option for severe infections.

Pharmacokinetics

Mean pharmacokinetic parameters reported in healthy adults after intravenous administration, typically studied in hospitalized patients with normal renal function.

References

1. Medellín-Garibay, SE, et al., & Barcia, E (2015). Population pharmacokinetics of gentamicin and dosing optimization for infants. Antimicrobial agents and chemotherapy 59(1) 482–489. DOI:10.1128/AAC.03464-14 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25385111

2. Boisson, M, et al., & Grégoire, N (2018). Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. The Journal of antimicrobial chemotherapy 73(10) 2830–2837. DOI:10.1093/jac/dky239 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947799

3. Lares-Asseff, I, et al., & Lugo Goytia, G (2016). Population Pharmacokinetics of Gentamicin in Mexican Children With Severe Malnutrition. The Pediatric infectious disease journal 35(8) 872–878. DOI:10.1097/INF.0000000000001204 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27420805

Revisions

• 06/2025 initial generated model