.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AA11_Gentamicin.Gentamicin_1

Information

Gentamicin is an aminoglycoside antibiotic used to treat serious bacterial infections, particularly those caused by gram-negative bacteria. It is one of the first-line therapies for septicemia, meningitis, and infections of the urinary tract, bone, and abdomen.

Pharmacokinetics

Mean PK parameters in neonates after intravenous administration. Neonates have higher volume of distribution and lower clearance due to immature renal function.

References

1. Medellín-Garibay, SE, et al., & Barcia, E (2015). Population pharmacokinetics of gentamicin and dosing optimization for infants. Antimicrobial agents and chemotherapy 59(1) 482–489. DOI:10.1128/AAC.03464-14 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25385111

2. Boisson, M, et al., & Grégoire, N (2018). Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. The Journal of antimicrobial chemotherapy 73(10) 2830–2837. DOI:10.1093/jac/dky239 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947799

3. Lares-Asseff, I, et al., & Lugo Goytia, G (2016). Population Pharmacokinetics of Gentamicin in Mexican Children With Severe Malnutrition. The Pediatric infectious disease journal 35(8) 872–878. DOI:10.1097/INF.0000000000001204 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27420805

Revisions

• 06/2025 initial generated model