.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AA12_Tobramycin.Tobramycin

Information

name:Tobramycin
ATC code:S01AA12
route:intravenous
n-compartments2

Tobramycin is an aminoglycoside antibiotic primarily used to treat serious bacterial infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. It is commonly used in ophthalmic formulations and is approved for both systemic and topical use.

Pharmacokinetics

Pharmacokinetics in healthy adult volunteers after intravenous administration.

References

  1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

  2. Praet, A, et al., & Goutelle, S (2021). Population Pharmacokinetic Modeling and Dosing Simulations of Tobramycin in Pediatric Patients with Cystic Fibrosis. Antimicrobial agents and chemotherapy 65(10) e0073721–None. DOI:10.1128/AAC.00737-21 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34280011

  3. Bloomfield, C, et al., & Hennig, S (2016). Assessing Predictive Performance of Published Population Pharmacokinetic Models of Intravenous Tobramycin in Pediatric Patients. Antimicrobial agents and chemotherapy 60(6) 3407–3414. DOI:10.1128/AAC.02654-15 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27001806

Revisions


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