.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AA14_Benzylpenicillin.Benzylpenicillin

Information

Benzylpenicillin, also known as penicillin G, is a beta-lactam antibiotic primarily used for the treatment of susceptible bacterial infections such as pneumococcal pneumonia, streptococcal infections, meningitis, anthrax, syphilis, and diphtheria. It is administered mainly intravenously or intramuscularly due to poor oral bioavailability. Benzylpenicillin is still approved and widely used today for the treatment of various infections.

Pharmacokinetics

Pharmacokinetics of intravenous benzylpenicillin in healthy adult individuals.

References

1. Bos, JC, et al., & Prins, JM (2018). Pharmacokinetics and Pharmacodynamic Target Attainment of Benzylpenicillin in an Adult Severely Ill Sub-Saharan African Patient Population. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 66(8) 1261–1269. DOI:10.1093/cid/cix961 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29112711

2. Bijleveld, YA, et al., & Mathôt, RAA (2018). Evaluation of a System-Specific Function To Describe the Pharmacokinetics of Benzylpenicillin in Term Neonates Undergoing Moderate Hypothermia. Antimicrobial agents and chemotherapy 62(4) –. DOI:10.1128/AAC.02311-17 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29378710

3. Bock, M, et al., & Moser, C (2025). Target attainment of benzylpenicillin in patients with infective endocarditis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases None –. DOI:10.1016/j.cmi.2025.04.025 PUBMED:https://pubmed.ncbi.nlm.nih.gov/40306489

Revisions

• 06/2025 initial generated model