.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AA19_Ampicillin.Ampicillin

Information

Ampicillin is a broad-spectrum beta-lactam antibiotic of the aminopenicillin class, primarily used to treat bacterial infections such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis. It is generally administered intravenously, intramuscularly or orally, and remains in clinical use today, with specific ophthalmic (S01AA19) use for ocular infections.

Pharmacokinetics

Pharmacokinetic parameters for ampicillin in healthy adult subjects following intravenous administration.

References

1. Setiawan, E, et al., & Roberts, JA (2023). Population Pharmacokinetics and Dosing Simulations of Ampicillin and Sulbactam in Hospitalised Adult Patients. Clinical pharmacokinetics 62(4) 573–586. DOI:10.1007/s40262-023-01219-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36853585

2. Santavy, P, et al., & Urbanek, K (2023). Population pharmacokinetics of three alternative prophylactic antibiotics during cardiac surgery with extracorporeal circulation. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 167(2) 208–211. DOI:10.5507/bp.2022.033 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35775358

3. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

Revisions

• 06/2025 initial generated model