.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AA26_Azithromycin.Azithromycin

Information

Azithromycin is a macrolide antibiotic used for the treatment of various bacterial infections, including respiratory tract, skin, ear, and eye infections. For ophthalmic use (ATC code S01AA26), it is primarily used as eye drops for bacterial conjunctivitis. Azithromycin is approved for medical use and routinely prescribed in clinical practice.

Pharmacokinetics

Ophthalmic administration, healthy adults, pharmacokinetic parameters estimated from available publications focused mainly on systemic use; direct ophthalmic PK parameters are limited.

References

1. Wu, F, et al., & Cui, Y (2019). Population Pharmacokinetic Modeling of Azithromycin Eyedrops in Tears Following Single-Dose Topical Administration in Healthy Volunteers. European journal of drug metabolism and pharmacokinetics 44(3) 371–378. DOI:10.1007/s13318-018-0522-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30357610

2. Asano, N, et al., & Kawazu, K (2017). Limited Azithromycin Localization to Rabbit Meibomian Glands Revealed by LC-MS-Based Bioanalysis and DESI Imaging. Biological & pharmaceutical bulletin 40(9) 1586–1589. DOI:10.1248/bpb.b17-00288 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28867744

3. Torkildsen, G, & O'Brien, TP (2008). Conjunctival tissue pharmacokinetic properties of topical azithromycin 1% and moxifloxacin 0.5% ophthalmic solutions: a single-dose, randomized, open-label, active-controlled trial in healthy adult volunteers. Clinical therapeutics 30(11) 2005–2014. DOI:10.1016/j.clinthera.2008.10.020 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19108788

Revisions

• 06/2025 initial generated model