.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AE01_Ofloxacin.Ofloxacin

Information

name:Ofloxacin
ATC code:S01AE01
route:oral
n-compartments2

Ofloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and eye infections. It inhibits bacterial DNA gyrase and topoisomerase IV. Ofloxacin is approved for use worldwide and remains a commonly used antibiotic both systemically and as an ophthalmic agent.

Pharmacokinetics

Pharmacokinetic parameters for ofloxacin in healthy adult subjects following a single oral dose.

References

  1. Jaruratanasirikul, S, et al., & Samaeng, M (2018). Population Pharmacokinetics and Pharmacodynamics Modeling of Oral Levofloxacin. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 99(8) 886–892. PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947489

  2. Stambaugh, JJ, et al., & Peloquin, CA (2002). Ofloxacin population pharmacokinetics in patients with tuberculosis. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 6(6) 503–509. DOI:10.5588/09640569513011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12068983

  3. Zhang, J, et al., & Zhang, YY (2009). Population pharmacokinetics of oral levofloxacin 500 mg once-daily dosage in community-acquired lower respiratory tract infections: results of a prospective multicenter study in China. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 15(5) 293–300. DOI:10.1007/s10156-009-0714-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19856067

Revisions


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