.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AE01_Ofloxacin.Ofloxacin_1 .Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AE01_Ofloxacin.Ofloxacin_1| name: | Ofloxacin_1 |
| ATC code: | S01AE01_1 | route: | intravenous |
| n-compartments | 2 |
Ofloxacin is a broad-spectrum fluoroquinolone antibiotic used for several types of bacterial infections. It is listed in many formularies and approved for human use both systemically and ophthalmically.
Reported pharmacokinetic parameters for intravenous administration in healthy adult volunteers.
Jaruratanasirikul, S, et al., & Samaeng, M (2018). Population Pharmacokinetics and Pharmacodynamics Modeling of Oral Levofloxacin. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 99(8) 886–892. PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947489
Zhang, L, et al., & Zhang, JW (2002). Pharmacokinetics of multiple intravenous instillation of levofloxacin in Chinese healthy subjects. Acta pharmacologica Sinica 23(4) 381–384. PUBMED:https://pubmed.ncbi.nlm.nih.gov/11931699
Preston, SL, et al., & Corrado, M (1998). Levofloxacin population pharmacokinetics and creation of a demographic model for prediction of individual drug clearance in patients with serious community-acquired infection. Antimicrobial agents and chemotherapy 42(5) 1098–1104. DOI:10.1128/AAC.42.5.1098 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9593134