.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AE03_Ciprofloxacin.Ciprofloxacin

Information

Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections, including urinary tract infections, respiratory tract infections, and eye infections. It is approved for both systemic and ophthalmic uses in many countries.

Pharmacokinetics

Two-compartment model in healthy adult volunteers after intravenous administration.

References

1. Hirt, D, et al., & Benaboud, S (2021). Population pharmacokinetics of intravenous and oral ciprofloxacin in children to optimize dosing regimens. European journal of clinical pharmacology 77(11) 1687–1695. DOI:10.1007/s00228-021-03174-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34160669

2. Abdulla, A, et al., & Koch, BCP (2020). Population pharmacokinetics and target attainment of ciprofloxacin in critically ill patients. European journal of clinical pharmacology 76(7) 957–967. DOI:10.1007/s00228-020-02873-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32307575

3. van Rhee, KP, et al., & Knibbe, CAJ (2022). Ciprofloxacin Pharmacokinetics After Oral and Intravenous Administration in (Morbidly) Obese and Non-obese Individuals: A Prospective Clinical Study. Clinical pharmacokinetics 61(8) 1167–1175. DOI:10.1007/s40262-022-01130-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35641862

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)