.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AE03_Ciprofloxacin.Ciprofloxacin_1 .Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AE03_Ciprofloxacin.Ciprofloxacin_1| name: | Ciprofloxacin_1 |
| ATC code: | S01AE03_1 | route: | ophthalmic |
| n-compartments | 1 |
Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections, including urinary tract infections, respiratory tract infections, and eye infections. It is approved for both systemic and ophthalmic uses in many countries.
One-compartment model following topical ophthalmic administration (eye drops) in healthy subjects.
Morlet, N, et al., & Lam, CM (2000). Pharmacokinetics of ciprofloxacin in the human eye: a clinical study and population pharmacokinetic analysis. Antimicrobial agents and chemotherapy 44(6) 1674–1679. DOI:10.1128/AAC.44.6.1674-1679.2000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10817727
Hendrix, DV, et al., & Cox, SK (2007). Pharmacokinetics of topically applied ciprofloxacin in equine tears. Veterinary ophthalmology 10(6) 344–347. DOI:10.1111/j.1463-5224.2007.00566.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/17970994
Di Marco, MP, et al., & Ducharme, MP (2004). A population pharmacokinetic-metabolism model for individualizing ciprofloxacin therapy in ophthalmology. Therapeutic drug monitoring 26(4) 401–407. DOI:10.1097/00007691-200408000-00010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15257070