.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AE05_Levofloxacin.Levofloxacin

Information

Levofloxacin is a broad-spectrum fluoroquinolone antibiotic used for the treatment of various bacterial infections, including respiratory tract infections, urinary tract infections, and skin infections. It is an approved medication and is widely used in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers.

References

1. Canouï, E, et al., & Benaboud, S (2022). Oral levofloxacin: population pharmacokinetics model and pharmacodynamics study in bone and joint infections. The Journal of antimicrobial chemotherapy 77(5) 1344–1352. DOI:10.1093/jac/dkac031 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35178577

2. Boonpeng, A, et al., & Samaeng, M (2021). Population pharmacokinetics of oral levofloxacin in healthy volunteers and dosing optimization for multidrug-resistant tuberculosis therapy. Biopharmaceutics & drug disposition 42(7) 329–337. DOI:10.1002/bdd.2294 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34117648

3. Jaruratanasirikul, S, et al., & Samaeng, M (2018). Population Pharmacokinetics and Pharmacodynamics Modeling of Oral Levofloxacin. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 99(8) 886–892. PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947489

Revisions

• 06/2025 initial generated model