.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AE07_Moxifloxacin.Moxifloxacin

Information

name:Moxifloxacin
ATC code:S01AE07
route:ocular
n-compartments1

Moxifloxacin is a fourth-generation fluoroquinolone antibiotic used for the treatment of bacterial infections. It is active against a broad spectrum of Gram-positive and Gram-negative pathogens and is commonly used to treat respiratory tract infections, skin infections, and certain types of conjunctivitis. Moxifloxacin with ATC code S01AE07 refers specifically to its ophthalmological (eye drop) use. The drug is approved for use in many countries and is generally well tolerated.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after single and repeated topical ocular administration.

References

  1. Segreti, J, et al., & Bertino, JS (2012). Challenges in assessing microbial susceptibility and predicting clinical response to newer-generation fluoroquinolones. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 28(1) 3–11. DOI:10.1089/jop.2011.0072 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21999341

  2. Chang, MH, & Fung, HB (2010). Besifloxacin: a topical fluoroquinolone for the treatment of bacterial conjunctivitis. Clinical therapeutics 32(3) 454–471. DOI:10.1016/j.clinthera.2010.03.013 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20399984

  3. Torkildsen, G, & O'Brien, TP (2008). Conjunctival tissue pharmacokinetic properties of topical azithromycin 1% and moxifloxacin 0.5% ophthalmic solutions: a single-dose, randomized, open-label, active-controlled trial in healthy adult volunteers. Clinical therapeutics 30(11) 2005–2014. DOI:10.1016/j.clinthera.2008.10.020 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19108788

Revisions


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