.Pharmacolibrary.Drugs.S_SensoryOrgans.S01A_Antiinfectives.S01AE09_Tosufloxacin.Tosufloxacin

Information

Tosufloxacin is a fluoroquinolone antibacterial agent primarily used for the treatment of various bacterial infections. It has broad-spectrum activity against both Gram-positive and Gram-negative organisms. While widely used in Japan for respiratory, urinary tract, and ophthalmic infections, its use is restricted or not approved in several countries (such as the US and Europe), partially due to concerns regarding adverse effects including severe toxicity.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult Japanese volunteers after single oral administration.

References

1. Yamamoto, H, et al., & Sugano, K (2023). Application of Population Balance Model to Simulate Precipitation of Weak Base and Zwitterionic Drugs in Gastrointestinal pH Environment. Molecular pharmaceutics 20(4) 2266–2275. DOI:10.1021/acs.molpharmaceut.3c00088 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36929729

2. Oonishi, Y, et al., & Yamaguchi, K (2007). Effect of GrlA mutation on the development of quinolone resistance in Staphylococcus aureus in an in vitro pharmacokinetic model. The Journal of antimicrobial chemotherapy 60(5) 1030–1037. DOI:10.1093/jac/dkm344 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17827137

Revisions

• 06/2025 initial generated model