.Pharmacolibrary.Drugs.S_SensoryOrgans.S01B_AntiinflammatoryAgents.S01BC03_Diclofenac.Diclofenac

Information

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) widely used for the treatment of pain and inflammation in conditions such as rheumatoid arthritis, osteoarthritis, and postoperative pain. Diclofenac is approved and commonly prescribed today in various formulations including oral, topical, and ophthalmic preparations.

Pharmacokinetics

Pharmacokinetics reported for healthy adult volunteers after single oral administration.

References

1. Moore, RA, et al., & Straube, S (2015). Effects of food on pharmacokinetics of immediate release oral formulations of aspirin, dipyrone, paracetamol and NSAIDs - a systematic review. British journal of clinical pharmacology 80(3) 381–388. DOI:10.1111/bcp.12628 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25784216

2. Standing, JF, et al., & Wong, IC (2008). Population pharmacokinetics of oral diclofenac for acute pain in children. British journal of clinical pharmacology 66(6) 846–853. DOI:10.1111/j.1365-2125.2008.03289.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/19032726

3. Lötsch, J, et al., & Kobal, G (2000). Population pharmacokinetics of fast release oral diclofenac in healthy volunteers: relation to pharmacodynamics in an experimental pain model. Pharmaceutical research 17(1) 77–84. DOI:10.1023/a:1007574710140 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10714612

Revisions

• 06/2025 initial generated model