.Pharmacolibrary.Drugs.S_SensoryOrgans.S01B_AntiinflammatoryAgents.S01BC06_Piroxicam.Piroxicam

Information

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) used to relieve symptoms of painful inflammatory conditions such as arthritis. It produces its effects by inhibiting prostaglandin synthesis through non-selective inhibition of cyclooxygenase (COX-1 and COX-2) enzymes. Piroxicam is currently approved and widely used in clinical practice for the treatment of pain and inflammation.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult subjects, both sexes, after a single oral dose.

References

1. Palma-Aguirre, JA, et al., & González-de la Parra, M (2010). Relative bioavailability of two oral formulations of piroxicam 20 mg: a single-dose, randomized-sequence, open-label, two-period crossover comparison in healthy Mexican adult volunteers. Clinical therapeutics 32(2) 357–364. DOI:10.1016/j.clinthera.2010.02.002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20206793

2. Calvo, AM, et al., & Santos, CF (2016). Effective method for the detection of piroxicam in human plasma using HPLC. Brazilian oral research 30(1) –. DOI:10.1590/1807-3107BOR-2016.vol30.0058 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27223141

3. Mailhot, C, et al., & Ward, JR (1986). The effect of cimetidine on serum concentrations of piroxicam. Pharmacotherapy 6(3) 112–117. DOI:10.1002/j.1875-9114.1986.tb03464.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/3488542

Revisions

• 06/2025 initial generated model