.Pharmacolibrary.Drugs.S_SensoryOrgans.S01E_AntiglaucomaPreparationsAndMiotics.S01EA03_Apraclonidine.Apraclonidine .Pharmacolibrary.Drugs.S_SensoryOrgans.S01E_AntiglaucomaPreparationsAndMiotics.S01EA03_Apraclonidine.Apraclonidine| name: | Apraclonidine | |
| ATC code: | S01EA03 | route: | topical |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 1.5 | L |
| clearance: | 0.6 | L/h/kg |
| other parameters in model implementation | ||
Apraclonidine is an alpha-2 adrenergic agonist primarily used in ophthalmology to reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It is commonly administered topically as eye drops. Apraclonidine is approved for short-term control of elevated IOP, such as after laser eye surgery, due to tachyphylaxis and side effects with longer-term use.
Estimated pharmacokinetic parameters for healthy adult individuals after topical ophthalmic administration. No detailed clinical population PK studies or compartmental model publications are available; all parameter values are estimated based on general knowledge of adrenergic agonists and limited data from product labels.