.Pharmacolibrary.Drugs.S_SensoryOrgans.S01E_AntiglaucomaPreparationsAndMiotics.S01EC03_Dorzolamide.Dorzolamide .Pharmacolibrary.Drugs.S_SensoryOrgans.S01E_AntiglaucomaPreparationsAndMiotics.S01EC03_Dorzolamide.Dorzolamide| name: | Dorzolamide |
| ATC code: | S01EC03 | route: | ophthalmic |
| n-compartments | 1 |
Dorzolamide is a carbonic anhydrase inhibitor primarily used as an ophthalmic solution to reduce elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It is approved and widely used in clinical practice today.
Pharmacokinetic parameters reported in healthy adult volunteers (ophthalmic administration). Dorzolamide accumulates in erythrocytes due to high affinity for carbonic anhydrase II. Minimal systemic exposure due to local ocular administration.
Schmitz, K, et al., & Behrens-Baumann, W (1999). Population pharmacokinetics of 2% topical dorzolamide in the aqueous humor of humans. Investigative ophthalmology & visual science 40(7) 1621–1624. PUBMED:https://pubmed.ncbi.nlm.nih.gov/10359348