.Pharmacolibrary.Drugs.S_SensoryOrgans.S01E_AntiglaucomaPreparationsAndMiotics.S01ED01_Timolol.Timolol

Information

Timolol is a non-selective beta-adrenergic antagonist used primarily to treat elevated intraocular pressure in ocular conditions such as glaucoma and ocular hypertension. It is also used systemically for hypertension, migraine prophylaxis, and occasionally for arrhythmias. Ophthalmic timolol is widely approved and used today.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers following single oral administration.

References

1. Olsen, GM, et al., & Drolet, BA (2020). Evaluating the Safety of Oral Propranolol Therapy in Patients With PHACE Syndrome. JAMA dermatology 156(2) 186–190. DOI:10.1001/jamadermatol.2019.3839 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31825455

2. Salminen, L, et al., & Iisalo, E (1989). Prevalence of debrisoquine oxidation phenotypes in glaucoma patients. International ophthalmology 13(1-2) 91–93. DOI:10.1007/BF02028645 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2787298

Revisions

• 06/2025 initial generated model