.Pharmacolibrary.Drugs.S_SensoryOrgans.S01F_MydriaticsAndCycloplegics.S01FA01_Atropine.Atropine

Information

name:Atropine
ATC code:S01FA01
route:intravenous
n-compartments2

Atropine is a competitive antagonist of the muscarinic acetylcholine receptors. It is used clinically to treat bradycardia, organophosphate poisoning, and as a pre-anesthetic to reduce salivation. Atropine remains an approved and widely used medication in current medical practice.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult individuals after intravenous administration.

References

  1. Ström, L, et al., & Ekstrand, C (2021). Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility. BMC veterinary research 17(1) 149–None. DOI:10.1186/s12917-021-02847-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33827566

  2. Sjödin, L, et al., & Al-Saffar, A (2011). Using pharmacokinetic modeling to determine the effect of drug and food on gastrointestinal transit in dogs. Journal of pharmacological and toxicological methods 64(1) 42–52. DOI:10.1016/j.vascn.2011.04.008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21596146

  3. Miyabe-Nishiwaki, T, et al., & Kanazawa, H (2013). Evaluation of the predictive performance of a pharmacokinetic model for propofol in Japanese macaques (Macaca fuscata fuscata). Journal of veterinary pharmacology and therapeutics 36(2) 169–173. DOI:10.1111/j.1365-2885.2012.01404.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/22568878

Revisions


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