.Pharmacolibrary.Drugs.S_SensoryOrgans.S01F_MydriaticsAndCycloplegics.S01FA02_Scopolamine.Scopolamine

Information

Scopolamine, also known as hyoscine, is a tropane alkaloid anticholinergic drug used primarily for the prevention of motion sickness, postoperative nausea and vomiting, and as a mydriatic and cycloplegic agent in ophthalmology. It is available in various formulations including oral, transdermal, and parenteral administration. Scopolamine is still in clinical use today, mainly for its antiemetic properties and ophthalmological purposes.

Pharmacokinetics

Pharmacokinetic parameters in healthy male adult volunteers after intravenous administration.

References

1. Alvarez-Jimenez, R, et al., & Stevens, J (2016). Model-based exposure-response analysis to quantify age related differences in the response to scopolamine in healthy subjects. British journal of clinical pharmacology 82(4) 1011–1021. DOI:10.1111/bcp.13031 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27273555

2. Hudson, RJ, et al., & Peterson, MD (2001). Pharmacokinetics of sufentanil in patients undergoing coronary artery bypass graft surgery. Journal of cardiothoracic and vascular anesthesia 15(6) 693–699. DOI:10.1053/jcan.2001.28311 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11748515

Revisions

• 06/2025 initial generated model