.Pharmacolibrary.Drugs.S_SensoryOrgans.S01F_MydriaticsAndCycloplegics.S01FA02_Scopolamine.Scopolamine_2

Information

Scopolamine, also known as hyoscine, is a tropane alkaloid anticholinergic drug used primarily for the prevention of motion sickness, postoperative nausea and vomiting, and as a mydriatic and cycloplegic agent in ophthalmology. It is available in various formulations including oral, transdermal, and parenteral administration. Scopolamine is still in clinical use today, mainly for its antiemetic properties and ophthalmological purposes.

Pharmacokinetics

Pharmacokinetic parameters in healthy adults after transdermal patch administration (behind the ear application for motion sickness prophylaxis).

References

1. Delgado-Charro, MB, & Guy, RH (2014). Effective use of transdermal drug delivery in children. Advanced drug delivery reviews 73 63–82. DOI:10.1016/j.addr.2013.11.014 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24333231

2. Berner, B, & John, VA (1994). Pharmacokinetic characterisation of transdermal delivery systems. Clinical pharmacokinetics 26(2) 121–134. DOI:10.2165/00003088-199426020-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8162656

3. Guay, DR (2003). Clinical pharmacokinetics of drugs used to treat urge incontinence. Clinical pharmacokinetics 42(14) 1243–1285. DOI:10.2165/00003088-200342140-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14606931

Revisions

• 06/2025 initial generated model