name: | Phenylephrine |
ATC code: | S01FB01 | route: | ophthalmic |
n-compartments | 1 |
Phenylephrine is a selective alpha-1 adrenergic receptor agonist used as a decongestant, to increase blood pressure in hypotensive states, and as a mydriatic agent for ophthalmic use. In ophthalmology (ATC code S01FB01), it is topically applied to dilate the pupil for diagnostic or surgical procedures. It is approved and widely used in clinical practice.
Pharmacokinetic parameters for phenylephrine following topical ophthalmic administration in healthy adult volunteers.
Atkinson, HC, et al., & Anderson, BJ (2015). Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review. European journal of clinical pharmacology 71(8) 931–938. DOI:10.1007/s00228-015-1876-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26022219
Seliniotaki, AK, et al., & Mataftsi, A (2022). Efficacy and safety of Mydriatic Microdrops for Retinopathy Of Prematurity Screening (MyMiROPS): study protocol for a non-inferiority crossover randomized controlled trial. Trials 23(1) 322–None. DOI:10.1186/s13063-022-06243-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35428316
Wang, ES, & Hammarlund, ER (1970). Corneal absorption reinforcement of certain mydriatics. Journal of pharmaceutical sciences 59(11) 1559–1563. DOI:10.1002/jps.2600591103 PUBMED:https://pubmed.ncbi.nlm.nih.gov/5495477