.Pharmacolibrary.Drugs.S_SensoryOrgans.S01G_DecongestantsAndAntiallergics.S01GA04_Oxymetazoline.Oxymetazoline .Pharmacolibrary.Drugs.S_SensoryOrgans.S01G_DecongestantsAndAntiallergics.S01GA04_Oxymetazoline.Oxymetazoline| name: | Oxymetazoline |
| ATC code: | S01GA04 | route: | nasal |
| n-compartments | 1 |
Oxymetazoline is an imidazoline derivative with sympathomimetic properties, primarily used as a topical nasal decongestant or in ophthalmic formulations to alleviate redness. It acts as an alpha-adrenergic agonist causing vasoconstriction of nasal mucosa and conjunctival blood vessels. Oxymetazoline is approved and commonly used today in both nasal spray and ophthalmic solutions for short-term relief of congestion and eye redness.
No published pharmacokinetic model was identified in peer-reviewed literature for oxymetazoline in humans. Parameters estimated based on available non-compartmental data and analogous alpha-agonist drugs.
Cartabuke, R, et al., & Jatana, KR (2021). Topical Nasal Decongestant Oxymetazoline: Safety Considerations for Perioperative Pediatric Use. Pediatrics 148(5) –. DOI:10.1542/peds.2021-054271 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34607935
Cacek, AT, et al., & Gopalakrishnan, M (2017). Population Pharmacokinetics of an Intranasally Administered Combination of Oxymetazoline and Tetracaine in Healthy Volunteers. Journal of clinical pharmacology 57(2) 247–254. DOI:10.1002/jcph.799 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27436060
Cartabuke, RS, et al., & Tobias, JD (2019). Hemodynamic and pharmacokinetic analysis of oxymetazoline use during nasal surgery in children. The Laryngoscope 129(12) 2775–2781. DOI:10.1002/lary.27760 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30786035