.Pharmacolibrary.Drugs.S_SensoryOrgans.S01G_DecongestantsAndAntiallergics.S01GA55_PhenylephrineCombination.PhenylephrineCombination

Information

name:PhenylephrineCombinations
ATC code:S01GA55
route:ophthalmic
n-compartments1

Phenylephrine is an alpha-1 adrenergic receptor agonist commonly used as a mydriatic (to dilate the pupil) and decongestant, often in combination with other agents for ophthalmic use. The ATC code S01GA55 corresponds to combinations containing phenylephrine for ophthalmic application. It is approved and still used in clinical ophthalmology.

Pharmacokinetics

No published pharmacokinetic studies were found specifically for ophthalmic phenylephrine-containing combinations (ATC S01GA55) in humans. Thus, pharmacokinetic parameters are estimated based on known properties of topical phenylephrine in adults.

References

  1. Atkinson, HC, et al., & Anderson, BJ (2015). Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review. European journal of clinical pharmacology 71(8) 931–938. DOI:10.1007/s00228-015-1876-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26022219

  2. Seliniotaki, AK, et al., & Mataftsi, A (2022). Efficacy and safety of Mydriatic Microdrops for Retinopathy Of Prematurity Screening (MyMiROPS): study protocol for a non-inferiority crossover randomized controlled trial. Trials 23(1) 322–None. DOI:10.1186/s13063-022-06243-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35428316

Revisions


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