.Pharmacolibrary.Drugs.S_SensoryOrgans.S01J_DiagnosticAgents.S01JA01_Fluorescein.Fluorescein

Information

Fluorescein is a synthetic organic compound used primarily as a diagnostic dye in ophthalmology for the assessment of corneal abrasions, vascular disorders, and to visualize blood vessels in the eye. It is approved for clinical use and is widely used today both topically and intravenously for retinal angiography.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers following intravenous bolus administration.

References

1. Rizk, DV, et al., & Molitoris, BA (2018). A Novel Method for Rapid Bedside Measurement of GFR. Journal of the American Society of Nephrology : JASN 29(6) 1609–1613. DOI:10.1681/ASN.2018020160 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29748326

2. Thorling, CA, et al., & Roberts, MS (2015). Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition. Drug metabolism and disposition: the biological fate of chemicals 43(1) 154–162. DOI:10.1124/dmd.114.060848 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25380806

3. Sim, DA, et al., & Fruttiger, M (2015). A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye. Disease models & mechanisms 8(11) 1479–1487. DOI:10.1242/dmm.019018 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26398933

Revisions

• 06/2025 initial generated model