.Pharmacolibrary.Drugs.S_SensoryOrgans.S01X_OtherOphthalmologicals.S01XA13_Alteplase.Alteplase

Information

Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent to treat acute ischemic stroke, acute myocardial infarction, and pulmonary embolism. It acts by catalyzing the conversion of plasminogen to plasmin, leading to the dissolution of blood clots. Alteplase is approved and in current clinical use in many countries.

Pharmacokinetics

Pharmacokinetic parameters observed predominantly in healthy adult volunteers and patients with myocardial infarction after intravenous administration.

References

1. Baek, JH, et al., & Bang, OY (2015). Predicting stroke outcome using clinical- versus imaging-based scoring system. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 24(3) 642–648. DOI:10.1016/j.jstrokecerebrovasdis.2014.10.009 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25576347

Revisions

• 06/2025 initial generated model