.Pharmacolibrary.Drugs.S_SensoryOrgans.S01X_OtherOphthalmologicals.S01XA25_Lifitegrast.Lifitegrast .Pharmacolibrary.Drugs.S_SensoryOrgans.S01X_OtherOphthalmologicals.S01XA25_Lifitegrast.Lifitegrast| name: | Lifitegrast |
| ATC code: | S01XA25 | route: | ophthalmic |
| n-compartments | 1 |
Lifitegrast is a lymphocyte function-associated antigen-1 (LFA-1) antagonist indicated for the treatment of dry eye disease (keratoconjunctivitis sicca) in adults. It is administered as a topical ophthalmic solution and is FDA-approved for this use.
Pharmacokinetic parameters are largely available from clinical summaries and product labels, as systemic exposure is minimal following ophthalmic administration. Population: Generally healthy adult subjects, both sexes, age ~18-80, normal renal and hepatic function, with dry eye disease.