.Pharmacolibrary.Drugs.S_SensoryOrgans.S01X_OtherOphthalmologicals.S01XA26_Riboflavin.Riboflavin .Pharmacolibrary.Drugs.S_SensoryOrgans.S01X_OtherOphthalmologicals.S01XA26_Riboflavin.Riboflavin| name: | Riboflavin | |
| ATC code: | S01XA26 | route: | ocular |
| compartments: | 1 | |
| dosage: | 0.3 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0.05 | L/h |
| other parameters in model implementation | ||
Riboflavin, also known as vitamin B2, is an essential water-soluble vitamin involved in energy metabolism in all living cells. It is used as a dietary supplement, in the treatment of riboflavin deficiency, and for prophylaxis of migraine headaches. For ophthalmic use (ATC code S01XA26), riboflavin is utilized as a photosensitizer in corneal collagen cross-linking procedures primarily for keratoconus. It is approved for these uses.
Estimated pharmacokinetic parameters for riboflavin, as specific peer-reviewed PK values for the ophthalmic ATC code S01XA26 use are not reported in published literature. Parameters based on general properties and estimated ocular bioavailability.
Price, MO, et al., & Price, FW (2018). Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia. Ophthalmology 125(4) 505–511. DOI:10.1016/j.ophtha.2017.10.034 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29203068