.Pharmacolibrary.Drugs.S_SensoryOrgans.S02A_Antiinfectives.S02AA01_Chloramphenicol.Chloramphenicol

Information

Chloramphenicol is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It is used to treat serious infections such as typhoid fever, meningitis, and eye infections, though its use has declined due to potentially severe side effects like aplastic anemia. It is still used in some countries, and topically for eye infections in others.

Pharmacokinetics

Pharmacokinetic parameters in healthy adults after intravenous administration.

References

1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

2. Zayyad, H, et al., & Paul, M (2017). Revival of old antibiotics: needs, the state of evidence and expectations. International journal of antimicrobial agents 49(5) 536–541. DOI:10.1016/j.ijantimicag.2016.11.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28162982

3. Ogutu, BR, et al., & Kokwaro, GO (2002). Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration. British journal of clinical pharmacology 54(6) 635–642. DOI:10.1046/j.1365-2125.2002.01689.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/12492612

Revisions

• 06/2025 initial generated model