.Pharmacolibrary.Drugs.S_SensoryOrgans.S02A_Antiinfectives.S02AA01_Chloramphenicol.Chloramphenicol_1

Information

Chloramphenicol is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It is used to treat serious infections such as typhoid fever, meningitis, and eye infections, though its use has declined due to potentially severe side effects like aplastic anemia. It is still used in some countries, and topically for eye infections in others.

Pharmacokinetics

Pharmacokinetic parameters in healthy adults after oral administration.

References

1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

2. Zayyad, H, et al., & Paul, M (2017). Revival of old antibiotics: needs, the state of evidence and expectations. International journal of antimicrobial agents 49(5) 536–541. DOI:10.1016/j.ijantimicag.2016.11.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28162982

3. Lugo Goytia, G, et al., & Mejía, CL (2000). Relationship between clinical and biologic variables and chloramphenicol pharmacokinetic parameters in pediatric patients with sepsis. The Annals of pharmacotherapy 34(3) 393–397. DOI:10.1345/aph.19050 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10917389

Revisions

• 06/2025 initial generated model