.Pharmacolibrary.Drugs.S_SensoryOrgans.S02A_Antiinfectives.S02AA14_Gentamicin.Gentamicin

Information

Gentamicin is an aminoglycoside antibiotic active against many Gram-negative and some Gram-positive bacteria. It is mainly used for the treatment of serious infections such as sepsis, respiratory tract infections, urinary tract infections, and endocarditis. Gentamicin is approved and widely used today, especially in hospital settings.

Pharmacokinetics

Pharmacokinetic parameters reported for adult healthy volunteers after intravenous administration.

References

1. Medellín-Garibay, SE, et al., & Barcia, E (2015). Population pharmacokinetics of gentamicin and dosing optimization for infants. Antimicrobial agents and chemotherapy 59(1) 482–489. DOI:10.1128/AAC.03464-14 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25385111

2. Boisson, M, et al., & Grégoire, N (2018). Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. The Journal of antimicrobial chemotherapy 73(10) 2830–2837. DOI:10.1093/jac/dky239 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947799

3. Lares-Asseff, I, et al., & Lugo Goytia, G (2016). Population Pharmacokinetics of Gentamicin in Mexican Children With Severe Malnutrition. The Pediatric infectious disease journal 35(8) 872–878. DOI:10.1097/INF.0000000000001204 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27420805

Revisions

• 06/2025 initial generated model