name: | Ofloxacin |
ATC code: | S02AA16 | route: | oral |
n-compartments | 1 |
Ofloxacin is a second-generation fluoroquinolone antibiotic used for the treatment of a variety of bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and certain types of ear and eye infections. It is approved for human use and is included in various national and international formularies.
Pharmacokinetic parameters reported in healthy adult volunteers following single oral administration. Values reflect population mean estimates.
Jaruratanasirikul, S, et al., & Samaeng, M (2018). Population Pharmacokinetics and Pharmacodynamics Modeling of Oral Levofloxacin. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 99(8) 886–892. PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947489
Stambaugh, JJ, et al., & Peloquin, CA (2002). Ofloxacin population pharmacokinetics in patients with tuberculosis. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 6(6) 503–509. DOI:10.5588/09640569513011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12068983
Zhang, J, et al., & Zhang, YY (2009). Population pharmacokinetics of oral levofloxacin 500 mg once-daily dosage in community-acquired lower respiratory tract infections: results of a prospective multicenter study in China. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 15(5) 293–300. DOI:10.1007/s10156-009-0714-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19856067