name: | Dexamethasone |
ATC code: | S02BA06 | route: | oral |
n-compartments | 2 |
Dexamethasone is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressant properties. It is used to treat a wide variety of conditions including allergic reactions, asthma, certain types of arthritis, cerebral edema, and in the management of COVID-19. It is an approved drug and widely used in clinical practice.
Pharmacokinetic parameters reported for healthy adult volunteers after oral administration.
Wen, J, et al., & Gonzalez, D (2024). Pharmacokinetics of Dexamethasone in Children and Adolescents with Obesity. Journal of clinical pharmacology 64(12) 1491–1504. DOI:10.1002/jcph.6108 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39120865
Wang, X, et al., & Kansra, V (2019). Population Pharmacokinetics of Rolapitant in Patients With Chemotherapy-Induced Nausea and Vomiting. Clinical pharmacology in drug development 8(7) 850–860. DOI:10.1002/cpdd.733 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31418538
Nakade, S, et al., & Miyata, Y (2008). Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting. Cancer chemotherapy and pharmacology 63(1) 75–83. DOI:10.1007/s00280-008-0713-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/18317761