.Pharmacolibrary.Drugs.S_SensoryOrgans.S02B_Corticosteroids.S02BA07_Betamethasone.Betamethasone .Pharmacolibrary.Drugs.S_SensoryOrgans.S02B_Corticosteroids.S02BA07_Betamethasone.Betamethasone| name: | Betamethasone |
| ATC code: | S02BA07 | route: | oral |
| n-compartments | 1 |
Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It is used in the treatment of various inflammatory and autoimmune conditions, including allergies, skin disorders, asthma, and as a part of management for certain ear conditions. Betamethasone is an approved medication and is still in use today in both topical and systemic formulations.
Estimated pharmacokinetic parameters for betamethasone in healthy adults based on available secondary literature, as no direct PK data for the S02BA07 (otic) route is available.
Krzyzanski, W, et al., & Jusko, WJ (2021). Population pharmacokinetic modeling of intramuscular and oral dexamethasone and betamethasone in Indian women. Journal of pharmacokinetics and pharmacodynamics 48(2) 261–272. DOI:10.1007/s10928-020-09730-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/33389521
Krzyzanski, W, et al., & Jusko, WJ (2021). Population pharmacodynamic modeling of intramuscular and oral dexamethasone and betamethasone effects on six biomarkers with circadian complexities in Indian women. Journal of pharmacokinetics and pharmacodynamics 48(3) 411–438. DOI:10.1007/s10928-021-09755-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/33954911
Lim, SY, et al., & Heard, CM (2020). Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases. International journal of pharmaceutics 573 118860–None. DOI:10.1016/j.ijpharm.2019.118860 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31759104