.Pharmacolibrary.Drugs.S_SensoryOrgans.S02D_OtherOtologicals.S02DA01_Lidocaine.Lidocaine

Information

Lidocaine is a local anesthetic and antiarrhythmic drug used for the treatment of ventricular arrhythmias and for local anesthesia in various medical procedures. It acts by blocking sodium channels, thereby inhibiting the initiation and conduction of nerve impulses. Lidocaine is widely approved and used in clinical practice today.

Pharmacokinetics

Adult healthy subjects, PK after intravenous administration.

References

1. Foong, KW, et al., & Loh, PS (2024). Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review. Clinical pharmacokinetics 63(5) 623–643. DOI:10.1007/s40262-024-01373-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38703307

2. Heath, C, et al., & Sommerfield, D (2023). Perioperative intravenous lidocaine use in children. Paediatric anaesthesia 33(5) 336–346. DOI:10.1111/pan.14608 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36424875

3. Crouch, CE, et al., & Fernandez-Bustamante, A (2023). Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation. Anesthesiology 138(1) 71–81. DOI:10.1097/ALN.0000000000004422 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36512707

Revisions

• 06/2025 initial generated model