.Pharmacolibrary.Drugs.S_SensoryOrgans.S03A_Antiinfectives.S03AA02_Tetracycline.Tetracycline

Information

Tetracycline is a broad-spectrum antibiotic from the tetracycline class that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It has been widely used for the treatment of various bacterial infections including respiratory tract infections, urinary tract infections, skin infections, and certain sexually transmitted diseases. While it is still used today, resistance has limited its application in some settings.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after a single oral dose.

References

1. Tao, RE, et al., & Feldman, SR (2023). Oral Tetracycline-Class Drugs in Dermatology: Impact of Food Intake on Absorption and Efficacy. Antibiotics (Basel, Switzerland) 12(7) –. DOI:10.3390/antibiotics12071152 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37508248

2. Thompson, EJ, et al., & Hornik, CP (2019). Population Pharmacokinetics of Doxycycline in Children. Antimicrobial agents and chemotherapy 63(12) –. DOI:10.1128/AAC.01508-19 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31548185

3. Rodvold, KA, et al., & Pai, MP (2020). Omadacycline: A Review of the Clinical Pharmacokinetics and Pharmacodynamics. Clinical pharmacokinetics 59(4) 409–425. DOI:10.1007/s40262-019-00843-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31773505

Revisions

• 06/2025 initial generated model