.Pharmacolibrary.Drugs.S_SensoryOrgans.S03A_Antiinfectives.S03AA06_Gentamicin.Gentamicin

Information

Gentamicin is an aminoglycoside antibiotic primarily used for the treatment of serious Gram-negative bacterial infections. It acts by inhibiting bacterial protein synthesis. While its systemic use is approved and common, the ATC code S03AA06 refers to gentamicin for ophthalmic use in the treatment of eye infections such as conjunctivitis and blepharitis.

Pharmacokinetics

Pharmacokinetic parameters reported for adult patients, receiving intravenous administration for systemic infections. Ophthalmic absorption is minimal and systemic exposure is generally considered negligible; therefore, the PK model is based on IV data in adults.

References

1. Medellín-Garibay, SE, et al., & Barcia, E (2015). Population pharmacokinetics of gentamicin and dosing optimization for infants. Antimicrobial agents and chemotherapy 59(1) 482–489. DOI:10.1128/AAC.03464-14 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25385111

2. Boisson, M, et al., & Grégoire, N (2018). Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. The Journal of antimicrobial chemotherapy 73(10) 2830–2837. DOI:10.1093/jac/dky239 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947799

3. Lares-Asseff, I, et al., & Lugo Goytia, G (2016). Population Pharmacokinetics of Gentamicin in Mexican Children With Severe Malnutrition. The Pediatric infectious disease journal 35(8) 872–878. DOI:10.1097/INF.0000000000001204 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27420805

Revisions

• 06/2025 initial generated model