.Pharmacolibrary.Drugs.S_SensoryOrgans.S03A_Antiinfectives.S03AA08_Chloramphenicol.Chloramphenicol

Information

Chloramphenicol is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It was historically used to treat serious infections like typhoid fever and meningitis, but its use is now limited due to rare but serious adverse effects such as aplastic anemia. Chloramphenicol is still approved for certain severe infections where alternative antibiotics are ineffective or contraindicated.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects after intravenous administration.

References

1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

2. Zayyad, H, et al., & Paul, M (2017). Revival of old antibiotics: needs, the state of evidence and expectations. International journal of antimicrobial agents 49(5) 536–541. DOI:10.1016/j.ijantimicag.2016.11.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28162982

3. Ogutu, BR, et al., & Kokwaro, GO (2002). Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration. British journal of clinical pharmacology 54(6) 635–642. DOI:10.1046/j.1365-2125.2002.01689.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/12492612

Revisions

• 06/2025 initial generated model