.Pharmacolibrary.Drugs.S_SensoryOrgans.S03B_Corticosteroids.S03BA01_Dexamethasone.Dexamethasone .Pharmacolibrary.Drugs.S_SensoryOrgans.S03B_Corticosteroids.S03BA01_Dexamethasone.Dexamethasone| name: | Dexamethasone |
| ATC code: | S03BA01 | route: | intravenous |
| n-compartments | 2 |
Dexamethasone is a potent synthetic corticosteroid used for its anti-inflammatory and immunosuppressant effects. It is used to treat a variety of conditions including allergic reactions, asthma, rheumatic problems, certain cancers, and for the management of cerebral edema. It remains widely approved and used in clinical practice.
Pharmacokinetic parameters reported for healthy adult volunteers following intravenous and oral administration.
Li, L, et al., & Endeman, H (2023). Population pharmacokinetics of dexamethasone in critically ill COVID-19 patients: Does inflammation play a role?. Journal of critical care 78 154395–None. DOI:10.1016/j.jcrc.2023.154395 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37542750
Guthrie, S (1991). The impact of dexamethasone pharmacokinetics on the DST: a review. Psychopharmacology bulletin 27(4) 565–576. PUBMED:https://pubmed.ncbi.nlm.nih.gov/1813902
Nijstad, AL, et al., & Zwaan, CM (2022). Overestimation of the effect of (fos)aprepitant on intravenous dexamethasone pharmacokinetics requires adaptation of the guidelines for children with chemotherapy-induced nausea and vomiting. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 30(12) 9991–9999. DOI:10.1007/s00520-022-07423-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36287279