modelInsects
Extends from Pharmacolibrary.Drugs.ATC.V.V01AA07.
Information
| name: | Insects | |
| ATC code: | V01AA07 | route: |
| compartments: | 0 | |
| dosage: | 1 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | |
| other parameters in model implementation | ||
The ATC code V01AA07 is classified for allergen extracts derived from insects, which are used in allergen immunotherapy to treat allergies to insect venoms, such as bee or wasp stings. These extracts are used mainly for desensitization in individuals with severe allergic reactions. Allergen extracts are biological products and are not usually described as drugs with classic pharmacology or pharmacokinetics, and there are no standard approvals for systemic administration as traditional drugs.
Pharmacokinetics
No pharmacokinetic parameters are available for insect allergen extracts in any population; such parameters are generally not reported for this class of agents as they are not systemically absorbed or measured in classical PK terms.
References
Hierlmeier, VR, et al., & Steiner, FM (2022). Persistent, bioaccumulative, and toxic chemicals in insects: Current state of research and where to from here?. The Science of the total environment 825 153830–None. DOI:10.1016/j.scitotenv.2022.153830 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35181364
Liu, XD, & Guo, HF (2019). Importance of endosymbionts Wolbachia and Rickettsia in insect resistance development. Current opinion in insect science 33 84–90. DOI:10.1016/j.cois.2019.05.003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31358201
Clark, AM (1976). Naturally occuring mutagens. Mutation research 32(3-4) 361–374. DOI:10.1016/0165-1110(76)90006-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/958226
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)