modelFood

Extends from Pharmacolibrary.Drugs.ATC.V.V01AA08.

Information

name:Food
ATC code:V01AA08
route:orally
compartments:1
dosage:1mg
volume of distribution:1L
clearance:0
other parameters in model implementation

Substances classified under ATC code V01AA08 refer to 'Test meals for functional investigation', commonly known as food used in diagnostic settings to assess gastrointestinal function. These are not drugs in the classical sense but standardized meals or food compositions employed to study digestion, absorption, or metabolism and are not intended as therapeutics. There is no approved pharmaceutical use for these products beyond clinical or experimental diagnostics.

Pharmacokinetics

Pharmacokinetic models for standard 'food' test meals do not exist, as foods are not pharmacological agents and lack defined PK parameters such as absorption, distribution, metabolism, and elimination in the conventional sense. No peer-reviewed pharmacokinetic model for test meals or 'food' with this ATC code exists.

References

  1. Chen, G, et al., & Nomikos, G (2018). Vortioxetine: Clinical Pharmacokinetics and Drug Interactions. Clinical pharmacokinetics 57(6) 673–686. DOI:10.1007/s40262-017-0612-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29189941

  2. Greenberg, RG, et al., & Walter, EB (2022). Population Pharmacokinetics of Moxifloxacin in Children. Paediatric drugs 24(2) 163–173. DOI:10.1007/s40272-022-00493-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35284983

  3. Fernandez-Teruel, C, et al., & Zhou, D (2024). Population Pharmacokinetics of Capivasertib in Patients with Advanced or Metastatic Solid Tumours. Clinical pharmacokinetics 63(8) 1191–1204. DOI:10.1007/s40262-024-01407-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/39127854

Parameters

TypeNameDefaultDescription
Modelica.Units.SI.Massweight (from PK_1C)75patient weight (kg)
Modelica.Units.SI.SpecificVolumeVdPerKg (from PK_1C)0.9Volume of distribution (L/kg)
Modelica.Units.SI.MassFractionF (from PK_1C)0.8bioavailiability (0-1)
Pharmacolibrary.Types.ClearanceCl (from PK_1C)20clearance
Modelica.Units.SI.TimeadminTime (from PK_1C)60first administration time (s)
Modelica.Units.SI.TimeadminDuration (from PK_1C)600administration duration (s)
Modelica.Units.SI.TimeadminPeriod (from PK_1C)8*60*60period of administration (default 8 hours)(s)
Pharmacolibrary.Types.MassadminMass (from PK_1C)1000administration mass (mg)
IntegeradminCount (from PK_1C)8number of dose administered (1)
Pharmacolibrary.Types.VolumeVd (from PK_1C)VdPerKg*weightVolume of distribution (m3)
Pharmacolibrary.Types.MassConcentrationCmin (from PK_1C)0.004minimal therapeutic range
Pharmacolibrary.Types.MassConcentrationCmax (from PK_1C)0.008minimal therapeutic range
Pharmacolibrary.Types.MassConcentrationCtox_peak (from PK_1C)0.012toxicity peak level
Pharmacolibrary.Types.MassConcentrationCtox_trough (from PK_1C)0.006toxicity trough level

Connectors

TypeNameDefaultDescription
Types.ConcentrationOutputC_central (from PK_1C)
Interfaces.ConcentrationPort_bcentralCPort (from PK_1C)

Components

TypeNameDefaultDescription
Pharmacokinetic.NoPerfusedTissueCompartmentcentral (from PK_1C)
Pharmacokinetic.ClearanceDrivenEliminationelim (from PK_1C)
Sources.PeriodicDoseperiodicDose (from PK_1C)
Modelica.Units.SI.Timet1_2 (from PK_1C)elimination half-life

Revisions

  • 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)