modelAnimals
Extends from Pharmacolibrary.Drugs.ATC.V.V01AA11.
Information
| name: | Animals | |
| ATC code: | V01AA11 | route: |
| compartments: | 0 | |
| dosage: | 1 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | |
| other parameters in model implementation | ||
ATC code V01AA11 corresponds to allergens of animal origin used for diagnostic purposes, such as in allergen extracts for skin testing in suspected allergies. These are not conventional drugs but biological extracts derived from animal tissues. Such products are used for identifying allergic sensitivities and are generally not used therapeutically. They are approved and regulated for diagnostic use.
Pharmacokinetics
No published pharmacokinetic (PK) data available for allergens of animal origin classified under ATC code V01AA11. These agents are protein extracts used in very small and variable doses for diagnostic testing, not for systemic pharmacological effect. Thus, conventional PK parameters such as clearance, volume of distribution, bioavailability, and absorption rates are not established or typically reported.
References
Sheiner, LB, & Ludden, TM (1992). Population pharmacokinetics/dynamics. Annual review of pharmacology and toxicology 32 185–209. DOI:10.1146/annurev.pa.32.040192.001153 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1605567
Hurrell, R, & Egli, I (2010). Iron bioavailability and dietary reference values. The American journal of clinical nutrition 91(5) 1461S–1467S. DOI:10.3945/ajcn.2010.28674F PUBMED:https://pubmed.ncbi.nlm.nih.gov/20200263
Keizer, RJ, et al., & Beijnen, JH (2010). Clinical pharmacokinetics of therapeutic monoclonal antibodies. Clinical pharmacokinetics 49(8) 493–507. DOI:10.2165/11531280-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20608753
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)