.Pharmacolibrary.Drugs.V_Various.V03A_AllOtherTherapeuticProducts.V03AB14_Protamine.Protamine

Information

Protamine is a cationic polypeptide used clinically to reverse the anticoagulant effects of heparin, particularly during surgeries such as cardiac and vascular procedures. It acts by binding to heparin to form a stable complex, thereby neutralizing its anticoagulant activity. Protamine is used in hospital settings and is currently approved for clinical use.

Pharmacokinetics

Pharmacokinetic parameters estimated for healthy adult male volunteers after intravenous administration of protamine sulfate.

References

1. Jia, Z, et al., & Hou, X (2015). Pharmacokinetic model of unfractionated heparin during and after cardiopulmonary bypass in cardiac surgery. Journal of translational medicine 13 45–None. DOI:10.1186/s12967-015-0404-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25638272

Revisions

• 06/2025 initial generated model