.Pharmacolibrary.Drugs.V_Various.V03A_AllOtherTherapeuticProducts.V03AB34_Fomepizole.Fomepizole .Pharmacolibrary.Drugs.V_Various.V03A_AllOtherTherapeuticProducts.V03AB34_Fomepizole.Fomepizole| name: | Fomepizole |
| ATC code: | V03AB34 | route: | intravenous |
| n-compartments | 1 |
Fomepizole is a competitive inhibitor of alcohol dehydrogenase, used primarily as an antidote in poisoning with methanol or ethylene glycol. It is FDA-approved and commonly used in emergency settings to prevent toxic metabolite formation in patients who have ingested these substances.
Pharmacokinetic parameters obtained from healthy adult volunteers after intravenous administration.
Wallemacq, PE, et al., & Hantson, P (2004). Plasma and tissue determination of 4-methylpyrazole for pharmacokinetic analysis in acute adult and pediatric methanol/ethylene glycol poisoning. Therapeutic drug monitoring 26(3) 258–262. DOI:10.1097/00007691-200406000-00006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15167624