modelGlucarpidase
Extends from Pharmacolibrary.Drugs.ATC.V.V03AF09.
Information
| name: | Glucarpidase | |
| ATC code: | V03AF09 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 3900 | mg |
| volume of distribution: | 3.5 | L |
| clearance: | 2.4 | L/h |
| other parameters in model implementation | ||
Glucarpidase is an enzyme (carboxypeptidase G2) used to rapidly lower toxic plasma levels of methotrexate in patients with delayed methotrexate clearance due to renal impairment. It hydrolyzes methotrexate into inactive metabolites. The drug is approved for use in the United States for this specific indication.
Pharmacokinetics
Pharmacokinetics in adult patients with impaired renal function who received glucarpidase 50 Units/kg intravenously as a single dose.
References
Fukaya, Y, et al., & Kawamoto, H (2023). Development of a population pharmacokinetics and pharmacodynamics model of glucarpidase rescue treatment after high-dose methotrexate therapy. Frontiers in oncology 13 1003633–None. DOI:10.3389/fonc.2023.1003633 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36793598
Taylor, ZL, et al., & Ramsey, LB (2020). MTXPK.org: A Clinical Decision Support Tool Evaluating High-Dose Methotrexate Pharmacokinetics to Inform Post-Infusion Care and Use of Glucarpidase. Clinical pharmacology and therapeutics 108(3) 635–643. DOI:10.1002/cpt.1957 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32558929
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)