modelOxygen
Extends from Pharmacolibrary.Drugs.ATC.V.V03AN01.
Information
| name: | Oxygen | |
| ATC code: | V03AN01 | route: | inhalation |
| compartments: | 1 | |
| dosage: | 1000 | mg |
| volume of distribution: | 3 | L |
| clearance: | 240 | l/h |
| other parameters in model implementation | ||
Oxygen is a medical gas essential for cellular metabolism, widely used for the treatment of hypoxemia and hypoxia in medical conditions such as acute respiratory distress, chronic obstructive pulmonary disease (COPD), and during anesthesia and resuscitation. It is approved and in standard use in modern medicine.
Pharmacokinetics
Pharmacokinetic parameters for inhaled medicinal oxygen in healthy adult volunteers, not reported in any peer-reviewed pharmacokinetic model publications. Information is estimated based on physiological properties of oxygen transport and general gas pharmacokinetics.
References
Bateman, RM, et al., & Prandi, E (2016). 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Critical care (London, England) 20(Suppl 2) 94–None. DOI:10.1186/s13054-016-1208-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27885969
Pippard, BJ, et al., & Thelwall, PE (2021). Reproducibility of . Magnetic resonance in medicine 85(6) 3343–3352. DOI:10.1002/mrm.28660 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33507591
Drover, DR, & Lemmens, HJ (1998). Population pharmacodynamics and pharmacokinetics of remifentanil as a supplement to nitrous oxide anesthesia for elective abdominal surgery. Anesthesiology 89(4) 869–877. DOI:10.1097/00000542-199810000-00011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9778004
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)