modelNitrogen
Extends from Pharmacolibrary.Drugs.ATC.V.V03AN04.
Information
| name: | Nitrogen | |
| ATC code: | V03AN04 | route: |
| compartments: | 0 | |
| dosage: | 1 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | |
| other parameters in model implementation | ||
Nitrogen (ATC code V03AN04) is used as a medical gas primarily for cryosurgery, tissue freezing, and as a component of gas mixtures for respiratory support. It is not a pharmaceutical agent in the classical sense and is generally not 'administered' as a drug for systemic pharmacological effect. It remains an important tool in surgical and diagnostic procedures, but is not 'approved' as a therapeutic agent via classical drug mechanisms.
Pharmacokinetics
No systemic pharmacokinetic parameters are available for nitrogen when administered as a medical gas, as it is inert and not metabolized, absorbed, or subject to traditional PK modeling in humans.
References
Chen, D, et al., & Zhu, H (2024). Population pharmacokinetics, dosing optimization and clinical outcomes of biapenem in patients with sepsis. Frontiers in pharmacology 15 1388150–None. DOI:10.3389/fphar.2024.1388150 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38799155
Zuo, M, et al., & Zhu, L (2023). Population Pharmacokinetics of Tacrolimus in Pediatric Patients With Umbilical Cord Blood Transplant. Journal of clinical pharmacology 63(3) 298–306. DOI:10.1002/jcph.2162 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36196568
Barceloux, DG (1999). Molybdenum. Journal of toxicology. Clinical toxicology 37(2) 231–237. DOI:10.1081/clt-100102422 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10382558
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)