modelGlucose
Extends from Pharmacolibrary.Drugs.ATC.V.V04CA02.
Information
| name: | Glucose | |
| ATC code: | V04CA02 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 25000 | mg |
| volume of distribution: | 10 | L |
| clearance: | 120 | mL/min |
| other parameters in model implementation | ||
Glucose (ATC V04CA02) is a simple monosaccharide sugar used as a primary source of energy by the body. Glucose solutions are used medically to treat hypoglycemia, dehydration, and as a component in parenteral nutrition. It is also utilized in diagnostic testing of glucose tolerance. Glucose is an essential nutrient and approved for use worldwide.
Pharmacokinetics
Pharmacokinetic parameters represent adult healthy individuals following intravenous administration of glucose. Values are estimated based on published pharmacokinetic models in the literature, as primary sources do not report all requested parameters explicitly for glucose infusion used as a drug.
References
Graham, GG, et al., & Williams, KM (2011). Clinical pharmacokinetics of metformin. Clinical pharmacokinetics 50(2) 81–98. DOI:10.2165/11534750-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21241070
Alshaer, MH, et al., & Hosmann, A (2022). Meropenem Population Pharmacokinetics and Simulations in Plasma, Cerebrospinal Fluid, and Brain Tissue. Antimicrobial agents and chemotherapy 66(8) e0043822–None. DOI:10.1128/aac.00438-22 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35862739
Ng, CM, et al., & De León, DD (2018). Population pharmacokinetics of exendin-(9-39) and clinical dose selection in patients with congenital hyperinsulinism. British journal of clinical pharmacology 84(3) 520–532. DOI:10.1111/bcp.13463 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29077992
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)