.Pharmacolibrary.Drugs.V_Various.V04C_OtherDiagnosticAgents.V04CC02_MagnesiumSulfate.MagnesiumSulfate

Information

Magnesium sulfate is an inorganic salt used in medicine as an anticonvulsant, a tocolytic, and an electrolyte replenisher, primarily in the management of pre-eclampsia, eclampsia, and severe asthma exacerbations. It is also used for magnesium deficiency and as a laxative. It is approved and in use today for these indications.

Pharmacokinetics

Pharmacokinetic parameters were reported in healthy adult women, non-pregnant, after IV administration over 5 minutes.

References

1. da Costa, TX, et al., & Oliveira, AG (2020). Population Pharmacokinetics of Magnesium Sulfate in Preeclampsia and Associated Factors. Drugs in R&D 20(3) 257–266. DOI:10.1007/s40268-020-00315-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32642964

2. Brookfield, KF, et al., & Carvalho, B (2016). Pharmacokinetics and placental transfer of magnesium sulfate in pregnant women. American journal of obstetrics and gynecology 214(6) 737.e1–737.e7379. DOI:10.1016/j.ajog.2015.12.060 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26767791

3. Rower, JE, et al., & Finkelstein, Y (2025). Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations. Journal of clinical pharmacology 65(6) 665–674. DOI:10.1002/jcph.6179 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39775569

Revisions

• 06/2025 initial generated model